Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor
of the central nervous system and has a very poor prognosis. The current standard of care …

Herpes simplex virus (HSV) infections of humans were first documented in ancient Greece.
Greek scholars, particularly Hippocrates, used the word" herpes," meaning to creep or crawl …

G207 is a conditionally replicating derivative of herpes simplex virus (HSV) type-1 strain F
engineered with deletions of both γ 1 34.5 loci and a lacZ insertion disabling the UL 39 …

Oncolytic herpes simplex virus type 1 (HSV-1) vectors are promising therapeutic agents for
cancer. Their efficacy depends on the extent of both intratumoral viral replication and …

In the past 5 years, the field of oncolytic virus research has matured significantly and is
moving past the stage of being a laboratory novelty into a new era of preclinical and clinical …

We have previously demonstrated safety of G207, a doubly mutated (deletion of both γ 1
34.5 loci, insertional inactivation of UL 39) herpes simplex virus (HSV) for patients …

Malignant glioma is the most common primary brain tumor and carries a grim prognosis, with
a median survival of just over 14 months. Given the poor outcomes with standard-of-care …

Oncolytic herpes simplex virus type 1 (HSV-1) vectors are emerging as an effective and
powerful therapeutic approach for cancer. Replication-competent HSV-1 vectors with …

The importance of herpes simplex viruses (HSV) as human pathogens and the emerging
prospect of using mutant derivatives of HSV-1 as potential anti-cancer therapeutics have …

ATRX is one of the most frequently altered genes in solid tumors, and mutation is especially
frequent in soft tissue sarcomas. However, the role of ATRX in tumor development and …