Sarcoidosis is a systemic granulomatous inflammatory disease of unknown etiology. It
affects the lungs in over 90% of patients yet extra-pulmonary and multi-organ involvement is …

Sarcoidosis is an immune-mediated disorder. Its immunopathology has been steadily
mapped out over the past few decades. Despite this, the underpinning mechanisms for …

Granulomas are lumps of immune cells that can form in various organs. Most granulomas
appear unstructured, yet they have some resemblance to lymphoid organs. To better …

Sarcoidosis is a multi-organ granulomatous inflammatory disease of unknown etiology. Over
50% of patients will require treatment at some point in their disease and 10%–30% will …

Advancements in the understanding of sarcoidosis support its consideration as an
autoimmune disease. Sarcoidosis patients carry a higher risk of comorbid autoimmune …

Background Macrophages are pivotal cells in sarcoidosis. Monocytes-derived (MD)
macrophages have recently been demonstrated to play a major role especially in pulmonary …

Introduction: Sarcoidosis is a multi-organ disease with a wide range of clinical
manifestations and outcomes. A quarter of sarcoidosis patients require long-term treatment …

Rationale: Sarcoidosis is a multisystemic inflammatory disease characterized by the
formation of granulomas in response to persistent stimuli. The long pentraxin PTX3 …

Rationale: Sarcoidosis is a granulomatous disorder of unclear cause notable for abnormal
elevation of blood and tissue ACE1 (angiotensin converting enzyme 1) levels and activity …

Non-infectious inflammatory cutaneous granulomatous diseases including granuloma
annulare (GA), cutaneous sarcoidosis (CS), and necrobiosis lipoidica (NL) are diverse …