Tuberous sclerosis complex is a rare genetic disease associated with mutations in the TSC1
or TSC2 genes, which cause overactivation of the mTOR complex. In the past 5 years …

Autophagy is best known for its role in organelle and protein turnover, cell quality control,
and metabolism. The autophagic machinery has, however, also adapted to enable protein …

Maintaining a highly acidic lysosomal pH is central to cellular physiology. Here, we use
functional proteomics, single-particle cryo-EM, electrophysiology, and in vivo imaging to …

Mammalian cells can acquire exogenous amino acids through endocytosis and lysosomal
catabolism of extracellular proteins. In amino acid-replete environments, nutritional …

Endomembrane damage represents a form of stress that is detrimental for eukaryotic cells,.
To cope with this threat, cells possess mechanisms that repair the damage and restore …

Cell growth is regulated by the mammalian/mechanistic target of rapamycin complex 1
(mTORC1), which functions both as a nutrient sensor and a master controller of virtually all …

Host–virus protein–protein interactions play key roles in the life cycle of severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2). We conducted a comprehensive …

We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG)
formation and that the process termed membrane atg8ylation coordinates SG formation with …

The mechanistic Target of Rapamycin (mTOR) is a growth-related kinase that, in the context
of the mTOR complex 1 (mTORC1), touches upon most fundamental cellular processes …

Ras-GTPase-activating protein (SH3 domain)-binding protein (G3BP) is an RNA binding
protein. G3BP is a key component of stress granules (SGs) and can interact with many host …