M Chemudupati, AD Kenney, S Bonifati, A Zani… - … Et Biophysica Acta (BBA …, 2019 - Elsevier
Antiviral restriction factors are cellular proteins that inhibit the entry, replication, or spread of viruses. These proteins are critical components of the innate immune system and function to …
J Ryoo, J Choi, C Oh, S Kim, M Seo, SY Kim, D Seo… - Nature medicine, 2014 - nature.com
The HIV-1 restriction factor SAM domain–and HD domain–containing protein 1 (SAMHD1), is proposed to inhibit HIV-1 replication by depleting the intracellular dNTP pool,,. However …
W Daddacha, AE Koyen, AJ Bastien, PSE Head… - Cell reports, 2017 - cell.com
DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP …
The sterile alpha motif and HD domain-containing protein 1 (SAMHD1), a dNTPase, prevents the infection of nondividing cells by retroviruses, including HIV, by depleting the …
M Rentoft, K Lindell, P Tran… - Proceedings of the …, 2016 - National Acad Sciences
Even small variations in dNTP concentrations decrease DNA replication fidelity, and this observation prompted us to analyze genomic cancer data for mutations in enzymes involved …
KJ Seamon, Z Sun, LS Shlyakhtenko… - Nucleic acids …, 2015 - academic.oup.com
The HIV-1 restriction factor SAMHD1 is a tetrameric enzyme activated by guanine nucleotides with dNTP triphosphate hydrolase activity (dNTPase). In addition to this …
SAA Coggins, B Mahboubi, RF Schinazi, B Kim - Viruses, 2020 - mdpi.com
Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and maintenance of genomic information in both cells and a variety of viral pathogens. While the …
R Kohnken, KM Kodigepalli, L Wu - Molecular cancer, 2015 - Springer
Regulation of intracellular deoxynucleoside triphosphate (dNTP) pool is critical to genomic stability and cancer development. Imbalanced dNTP pools can lead to enhanced …
P Kapoor-Vazirani, SK Rath, X Liu, Z Shu… - Nature …, 2022 - nature.com
Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) has a dNTPase- independent function in promoting DNA end resection to facilitate DNA double-strand break …