Visualization of the cellular heterogeneity and spatial architecture of the tumor
microenvironment (TME) is becoming increasingly important to understand mechanisms of …

Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

Spatial omics technologies generate wealthy but highly complex datasets. Here we present
Spatial Omics DataBase (SODB), a web-based platform providing both rich data resources …

Single-cell (SC) analysis provides unique insight into individual cell dynamics and cell-to-
cell heterogeneity. Here, we utilize trapped ion mobility separation coupled with dual …

Artificial sweeteners are used as calorie-free sugar substitutes in many food products and
their consumption has increased substantially over the past years. Although generally …

In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-
immune microenvironment at the genomic, transcriptomic, and proteomic levels and have …

Metabolic status is crucial for stem cell functions; however, the metabolic heterogeneity of
endogenous stem cells has never been directly assessed. Here, we develop a platform for …

Spatial metabolomics is an emerging field of omics research that has enabled localizing
metabolites, lipids, and drugs in tissue sections, a feat considered impossible just two …

Spatial metabolomics is an emerging field of omics research that has enabled localizing
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …

We present a mass spectrometry imaging (MSI) approach for the comprehensive mapping of
neurotransmitter networks in specific brain regions. Our fluoromethylpyridinium-based …