Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In
this study, we establish that aging of the immune system, regardless of the age of the stroma …

DNA methylation is an epigenetic modification that plays a pivotal role in regulating gene
expression and, consequently, influences a wide variety of biological processes and …

DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …

Although aging is a conserved phenomenon across evolutionary distant species, aspects of
the aging process have been found to differ between males and females of the same …

Epigenetic alterations are a hallmark of aging and age‐related diseases. Computational
models using DNA methylation data can create “epigenetic clocks” which are proposed to …

Aging is characterized by decreasing physiological integration, reduced function, loss of
resilience, and increased risk of death. Paradoxically, although women live longer, they …

The genomic hypomethylation hypothesis of aging proposes that an overall decrease in
global DNA methylation occurs with age, and it has been argued that the decrease in global …

Decline in ovarian reserve with advancing age is associated with reduced fertility and the
emergence of metabolic disturbances, osteoporosis, and neurodegeneration. Recent …