The conversion of force into an electrical cellular signal is mediated by the opening of
different types of mechanosensitive ion channels (MSCs), including TREK/TRAAK K 2P …

Organisms of all phyla express mechanosensitive ion channels with a wide range of
physiological functions. In recent years, several classes of mechanically gated ion channels …

Teneurins are ancient metazoan cell adhesion receptors that control brain development and
neuronal wiring in higher animals. The extracellular C terminus binds the adhesion GPCR …

Usher syndrome type 1 F (USH1F), caused by mutations in the protocadherin-15 gene
(PCDH15), is characterized by congenital deafness, lack of balance, and progressive …

In the inner ear, the auditory and vestibular systems detect and translate sensory information
regarding sound and balance. The sensory cells that transform mechanical input into an …

Tip-links in the inner ear convey force from sound and trigger mechanotransduction. Here,
we present evidence that tip-links (collectively as heterotetrameric complexes of cadherins) …

Up to five distinct cell-surface specializations interconnect the stereocilia and the kinocilium
of the mature hair bundle in some species: kinocilial links, tip links, top connectors, shaft …

Cadherin EGF LAG seven-pass G-type receptors (CELSR) cadherins, members of the
cadherin superfamily, and adhesion G-protein-coupled receptors, play a vital role in cell–cell …

The mechanoelectrical transduction (MET) channel of cochlear hair cells is gated by the tip
link, but the mechanisms that establish the exquisite force sensitivity of this MET channel are …

The vertebrate inner ear, responsible for hearing and balance, is able to sense minute
mechanical stimuli originating from an extraordinarily broad range of sound frequencies and …