Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders

FV Brozovich, CJ Nicholson, CV Degen, YZ Gao… - Pharmacological …, 2016 - Elsevier
The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

Smooth muscle cell phenotypic switching in atherosclerosis

D Gomez, GK Owens - Cardiovascular research, 2012 - academic.oup.com
Smooth muscle cells (SMCs) possess remarkable phenotypic plasticity that allows rapid
adaptation to fluctuating environmental cues, including during development and progression …

Molecular regulation of vascular smooth muscle cell differentiation in development and disease

GK Owens, MS Kumar… - Physiological reviews, 2004 - journals.physiology.org
The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …

Regulation of differentiation of vascular smooth muscle cells

GK Owens - Physiological reviews, 1995 - journals.physiology.org
The vascular smooth muscle cell (SMC) in mature animals is a highly specialized cell whose
principal function is contraction. The fully differentiated or mature SMC proliferates at an …

Molecular regulation of contractile smooth muscle cell phenotype: implications for vascular tissue engineering

JA Beamish, P He, K Kottke-Marchant… - … Engineering Part B …, 2010 - liebertpub.com
The molecular regulation of smooth muscle cell (SMC) behavior is reviewed, with particular
emphasis on stimuli that promote the contractile phenotype. SMCs can shift reversibly along …

PDGF, TGF-β, and heterotypic cell–cell interactions mediate endothelial cell–induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate

KK Hirschi, SA Rohovsky, PA D'Amore - The Journal of cell biology, 1998 - rupress.org
We aimed to determine if and how endothelial cells (EC) recruit precursors of smooth
muscle cells and pericytes and induce their differentiation during vessel formation …

Haemangioblast commitment is initiated in the primitive streak of the mouse embryo

TL Huber, V Kouskoff, H Joerg Fehling, J Palis, G Keller - Nature, 2004 - nature.com
Haematopoietic and vascular cells are thought to arise from a common progenitor called the
haemangioblast. Support for this concept has been provided by embryonic stem (ES) cell …

In vitro blood–brain barrier models: current and perspective technologies

P Naik, L Cucullo - Journal of pharmaceutical sciences, 2012 - Elsevier
Even in the 21st century, studies aimed at characterizing the pathological paradigms
associated with the development and progression of central nervous system diseases are …

SM22α, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis

L Li, JM Miano, P Cserjesi, EN Olson - Circulation research, 1996 - Am Heart Assoc
SM22α is a calponin-related protein that is expressed specifically in adult smooth muscle. To
begin to define the mechanisms that regulate the establishment of the smooth muscle …

Calponin isoforms CNN1, CNN2 and CNN3: Regulators for actin cytoskeleton functions in smooth muscle and non-muscle cells

R Liu, JP Jin - Gene, 2016 - Elsevier
Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and
many types of non-muscle cells. Three homologous genes, CNN1, CNN2 and CNN 3 …