[HTML][HTML] From NASH to diabetes and from diabetes to NASH: mechanisms and treatment options

A Gastaldelli, K Cusi - JHEP reports, 2019 - Elsevier
The worldwide prevalence of non-alcoholic fatty liver disease (NAFLD) is estimated to have
reached 25% or more in adults. NAFLD is prevalent in obese individuals, but may also affect …

Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications

SM Francque, D Van Der Graaff, WJ Kwanten - Journal of hepatology, 2016 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become one of the most frequent chronic liver
diseases in the Western society and its prevalence is likely to rise even further. An …

Pathophysiology and mechanisms of nonalcoholic fatty liver disease

JT Haas, S Francque, B Staels - Annual review of physiology, 2016 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver disorders
characterized by abnormal hepatic fat accumulation, inflammation, and hepatocyte …

Pathophysiological, molecular and therapeutic issues of nonalcoholic fatty liver disease: an overview

S Marchisello, A Di Pino, R Scicali, F Urbano… - International journal of …, 2019 - mdpi.com
Nonalcoholic Fatty Liver Disease (NAFLD) represents the leading cause of liver disease in
developed countries but its diffusion is currently also emerging in Asian countries, in South …

Experimental models of liver fibrosis

S Crespo Yanguas, B Cogliati, J Willebrords… - Archives of …, 2016 - Springer
Hepatic fibrosis is a wound healing response to insults and as such affects the entire world
population. In industrialized countries, the main causes of liver fibrosis include alcohol …

[HTML][HTML] Nonalcoholic fatty liver disease: Evolving paradigms

A Lonardo, F Nascimbeni, M Maurantonio… - World journal of …, 2017 - ncbi.nlm.nih.gov
In the last years new evidence has accumulated on nonalcoholic fatty liver disease (NAFLD)
challenging the paradigms that had been holding the scene over the previous 30 years …

[HTML][HTML] Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease

G Gentric, V Maillet, V Paradis… - The Journal of …, 2015 - Am Soc Clin Investig
Polyploidization is one of the most dramatic changes that can occur in the genome. In the
liver, physiological polyploidization events occur during both liver development and …

Nonalcoholic fatty liver disease and type 2 diabetes: common pathophysiologic mechanisms

C Saponaro, M Gaggini, A Gastaldelli - Current diabetes reports, 2015 - Springer
Nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for advanced liver
disease, type 2 diabetes (T2DM), and cardiovascular diseases. The prevalence of NAFLD in …

Biomarkers in nonalcoholic fatty liver disease

MG Neuman, LB Cohen… - Canadian Journal of …, 2014 - Wiley Online Library
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver condition
characterized by insulin resistance, type 2 diabetes and fat accumulation in the liver that …

[HTML][HTML] Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review

TJ Severson, S Besur, HL Bonkovsky - World journal of …, 2016 - ncbi.nlm.nih.gov
AIM: To investigate roles of genetic polymorphisms in non-alcoholic fatty liver disease
(NAFLD) onset, severity, and outcome through systematic literature review. METHODS: The …