Zebrafish modeling of autism spectrum disorders, current status and future prospective

A Tayanloo-Beik, SK Hamidpour, M Abedi… - Frontiers in …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) refers to a complicated range of childhood
neurodevelopmental disorders which can occur via genetic or non-genetic factors. Clinically …

Using zebrafish to model autism spectrum disorder: a comparison of ASD risk genes between zebrafish and their mammalian counterparts

V Rea, TJ Van Raay - Frontiers in molecular neuroscience, 2020 - frontiersin.org
Autism spectrum disorders (ASDs) are a highly variable and complex set of neurological
disorders that alter neurodevelopment and cognitive function, which usually presents with …

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

H Serra, I Chivite, A Angulo-Urarte, A Soler… - Nature …, 2015 - nature.com
Coordinated activity of VEGF and Notch signals guides the endothelial cell (EC)
specification into tip and stalk cells during angiogenesis. Notch activation in stalk cells leads …

Buyang Huanwu Decoction promotes angiogenesis in myocardial infarction through suppression of PTEN and activation of the PI3K/Akt signalling pathway

X Han, G Zhang, G Chen, Y Wu, T Xu, H Xu… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Myocardial infarction (MI) is the most severe subtype of
coronary artery disease. Recent studies have demonstrated that the repair process and …

PTEN inhibits AMPK to control collective migration

F Peglion, L Capuana, I Perfettini, L Boucontet… - Nature …, 2022 - nature.com
Pten is one of the most frequently mutated tumour suppressor gene in cancer. PTEN is
generally altered in invasive cancers such as glioblastomas, but its function in collective cell …

[HTML][HTML] Recent advances in understanding the role of protein-tyrosine phosphatases in development and disease

AJ Hale, E Ter Steege, J den Hertog - Developmental Biology, 2017 - Elsevier
Protein-tyrosine phosphatases (PTPs) remove phosphate groups from tyrosine residues,
and thereby propagate or inhibit signal transduction, and hence influence cellular processes …

A new perspective on fungal metabolites: identification of bioactive compounds from fungi using zebrafish embryogenesis as read-out

J Hoeksma, T Misset, C Wever, J Kemmink… - Scientific reports, 2019 - nature.com
There is a constant need for new therapeutic compounds. Fungi have proven to be an
excellent, but underexplored source for biologically active compounds with therapeutic …

Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization

R Wild, A Klems, M Takamiya, Y Hayashi… - Nature …, 2017 - nature.com
Formation of organ-specific vasculatures requires cross-talk between developing tissue and
specialized endothelial cells. Here we show how developing zebrafish spinal cord neurons …

Multifaceted regulation of PTEN subcellular distributions and biological functions

T Liu, Y Wang, Y Wang, AM Chan - Cancers, 2019 - mdpi.com
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor
gene frequently found to be inactivated in over 30% of human cancers. PTEN encodes a 54 …

Exosomal miR-486 derived from bone marrow mesenchymal stem cells promotes angiogenesis following cerebral ischemic injury by regulating the PTEN/Akt pathway

H Bao, S Mao, X Hu, L Li, H Tao, J Zhou, L Xu… - Scientific Reports, 2024 - nature.com
Bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) have been shown to
promote angiogenesis after ischemic stroke, in which microRNAs (miRs) are believed to …