The nucleus pulposus microenvironment in the intervertebral disc: the fountain of youth?

JP Guerrero, S Häckel, AS Croft, S Hoppe… - European cells & …, 2021 - boris.unibe.ch
The intervertebral disc (IVD) is a complex tissue, and its degeneration remains a problem for
patients, without significant improvement in treatment strategies. This mostly age-related …

[HTML][HTML] Precision medicine strategies for spinal degenerative diseases: Injectable biomaterials with in situ repair and regeneration

X Zhao, H Ma, H Han, L Zhang, J Tian, B Lei… - Materials Today Bio, 2022 - Elsevier
As the population ages, spinal degeneration seriously affects quality of life in middle-aged
and elderly patients, and prevention and treatment remain challenging for clinical surgeons …

Role of the Wnt pathway in the formation, development, and degeneration of intervertebral discs

ZL Wu, QQ Xie, TC Liu, X Yang, GZ Zhang… - Pathology-Research and …, 2021 - Elsevier
Intervertebral disc degeneration (IVDD) is an age-related degenerative disease that is the
main cause of low back pain. It seriously affects the quality of life of patients and places a …

Repair of annulus fibrosus defects using decellularized annulus fibrosus matrix/chitosan hybrid hydrogels

C Liu, X Ge, Y Li - Journal of Orthopaedic Surgery and Research, 2024 - Springer
Degenerative disc disease is the leading cause of lower back and leg pain, considerably
impacting daily life and incurring substantial medical expenses for those affected. The …

IGF signaling in intervertebral disc health and disease

H Lin, S Tian, Y Peng, L Wu, Y Xiao, X Qing… - Frontiers in Cell and …, 2022 - frontiersin.org
Low back pain (LBP) is a common musculoskeletal symptom, which brings a lot of pain and
economic loss to patients. One of the most common causes of LBP is intervertebral disc …

Effects of etanercept, a tumor necrosis factor receptor fusion protein, on primary cell cultures prepared from intact human intervertebral disc tissue

T Caliskan, D Yasar Sirin… - Experimental and …, 2019 - spandidos-publications.com
The aim of the present study was to investigate the effects of etanercept (ETA), a tumor
necrosis factor (TNF) inhibitor, on human cell cultures prepared from intact intervertebral …

Are intervertebral disc tissue cells damaged when attempting to prevent thrombus formation using dabigatran, a new oral anticoagulant?

N Kaplan, N Karaarslan, İ Yılmaz, DY Şirin, FS Akgün… - 2019 - acikerisim.rumeli.edu.tr
AIM: To investigate the effect of dabigatran, a new oral anticoagulant, on human primary cell
cultures isolated from intact intervertebral disc tissue. MATERIAL and METHODS: Cell …

Drug Delivery Systems for Intervertebral Disc

IL Mohd Isa, S Masri, LA Elfawy, S Tahri… - Drug Delivery Systems …, 2024 - Springer
Intervertebral disc (IVD) degeneration is one of the most common degenerative joint
diseases that cause pain and disability in adults. It is also a major cause of chronic lower …

[引用][C] Evaluation of the effect of daptomycin, a glycopeptide agent, on intact intervertebral disc tissue

N Kaplan, İ Yılmaz, N Karaarslan… - Turkish …, 2019 - Turkish Neurosurgical Soc

[引用][C] Evaluation of the expression and proliferation of degenerative markers in primary cell cultures obtained from human intervertebral disc tissue

YE Kaya, H Akalan, İ Yılmaz… - Annals of …, 2020 - Annals of Medical Research …