Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

Since the clinical approval of imatinib, the discovery of protein kinase downregulators
entered a prosperous age. However, challenges still exist in the discovery of kinase …

Children with rare, relapsed or refractory cancers often face limited treatment options, and
few predictive biomarkers are available that can enable personalized treatment …

Rhabdomyosarcomas (RMS) are mesenchyme‐derived tumors and the most common
childhood soft tissue sarcomas. Treatment is intense, with a nevertheless poor prognosis for …

Functional precision medicine (fPM) offers an exciting, simplified approach to finding the
right applications for existing molecules and enhancing therapeutic potential. Integrative and …

Introduction: Tyrosine kinases are key mediators of intracellular signaling cascades and
aberrations in these proteins have been implicated in driving oncogenesis through the …

Background Despite the well described heterogeneity in glioblastoma (GBM), treatment is
standardized, and clinical trials investigate treatment effects at population level. Genomics …

Malignancies with extremely low incidences, such as less than 6 per 100,000 people
annually, are defined as rare cancers. Approximately 200 malignancies are classified in this …

The use of ex vivo drug sensitivity testing to predict drug activity in individual patients has
been actively explored for almost 50 years without delivering a generally useful predictive …

Comparative characteristics of small cell lung cancer and Ewing’s sarcoma: a narrative review -
PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …