For many years, cardiovascular disease (CVD) has been the leading cause of death around
the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid …

Heart failure is one of the leading causes of death worldwide and has been singled out as
an emerging epidemic. 1, 2 With a 5-year survival rate of 50%, heart failure poses a …

Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …

How Mycobacterium tuberculosis (Mtb) rewires macrophage energy metabolism to facilitate
survival is poorly characterized. Here, we used extracellular flux analysis to simultaneously …

Fibroblast to myofibroblast differentiation is crucial for the initial healing response but
excessive myofibroblast activation leads to pathological fibrosis. Therefore, it is imperative to …

Dendrobium is a traditional Chinese herb with anti-diabetic effects and has diverse
bibenzyls as well as phenanthrenes. Little is known about Dendrobium polyphenols anti …

Diabetes is predominant risk factor for cardiovascular diseases such as myocardial
infarction and heart failure. Recently, leukocytes, particularly neutrophils, macrophages, and …

Glycometabolism is well known for its roles as the main source of energy, which mainly
includes three metabolic pathways: oxidative phosphorylation, glycolysis and pentose …

Background Fibrosis and extracellular matrix remodeling are mediated by resident cardiac
fibroblasts (CFs). In response to injury, fibroblasts activate, differentiating into specialized …

Heart failure and cardiovascular disorders represent the leading cause of death in diabetic
patients. Here we present a systematic review of the main mechanisms underlying the …