The role of extracellular vesicles in cancer

R Kalluri, KM McAndrews - Cell, 2023 - cell.com
Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …

RNA delivery by extracellular vesicles in mammalian cells and its applications

K O'Brien, K Breyne, S Ughetto, LC Laurent… - … reviews Molecular cell …, 2020 - nature.com
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

The evolving translational potential of small extracellular vesicles in cancer

A Möller, RJ Lobb - Nature Reviews Cancer, 2020 - nature.com
Cancer-derived extracellular vesicles (EVs) are regarded as having promising potential to
be used as therapeutics and disease biomarkers. Mechanistically, EVs have been shown to …

Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents

HM Zhou, JG Zhang, X Zhang, Q Li - Signal transduction and targeted …, 2021 - nature.com
Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Recent advances of small extracellular vesicle biomarkers in breast cancer diagnosis and prognosis

Y Lee, J Ni, J Beretov, VC Wasinger, P Graham, Y Li - Molecular cancer, 2023 - Springer
Current clinical tools for breast cancer (BC) diagnosis are insufficient but liquid biopsy of
different bodily fluids has recently emerged as a minimally invasive strategy that provides a …

Extracellular vesicles: mediators of intercellular communication in tissue injury and disease

G Berumen Sánchez, KE Bunn, HH Pua… - Cell Communication and …, 2021 - Springer
Intercellular communication is a critical process that ensures cooperation between distinct
cell types and maintains homeostasis. EVs, which were initially described as cellular debris …

Exosomes and breast cancer drug resistance

X Dong, X Bai, J Ni, H Zhang, W Duan, P Graham… - Cell death & …, 2020 - nature.com
Drug resistance is a daunting challenge in the treatment of breast cancer (BC). Exosomes,
as intercellular communicative vectors in the tumor microenvironment, play an important role …

Extracellular vesicles in cancer drug resistance: roles, mechanisms, and implications

Q Yang, J Xu, J Gu, H Shi, J Zhang, J Zhang… - Advanced …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are cell‐derived nanosized vesicles that mediate cell‐to‐cell
communication via transporting bioactive molecules and thus are critically involved in …

Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology

W Hu, C Liu, ZY Bi, Q Zhou, H Zhang, LL Li, J Zhang… - Molecular cancer, 2020 - Springer
Extracellular vesicles (EVs), a class of heterogeneous membrane vesicles, are generally
divided into exosomes and microvesicles on basis of their origination from the endosomal …

VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites

B Barman, BH Sung, E Krystofiak, J Ping, M Ramirez… - Developmental Cell, 2022 - cell.com
RNA transfer via extracellular vesicles (EVs) influences cell phenotypes; however, lack of
information regarding biogenesis of RNA-containing EVs has limited progress in the field …