The increased production of derivatives of molecular oxygen and nitrogen in the form of
reactive oxygen species (ROS) and reactive nitrogen species (RNS) lead to molecular …

Mitochondrial dysfunction is a characteristic trait of human and rodent obesity, insulin
resistance and fatty liver disease. Here we show that high-fat diet (HFD) feeding causes …

The function of the adipose tissue is influenced by complex interactions between genetics,
epigenetics, and the environment, and its dysfunction can cause a variety of metabolic …

Abstract Dynamin-related protein 1 (DRP1) plays crucial roles in mitochondrial and
peroxisome fission. However, the mechanisms underlying the functional regulation of DRP1 …

The extracellular matrix (ECM) regulates cell behavior through signal transduction and
provides a suitable place for cell survival. As one of the major components of the …

Cardiometabolic diseases present an escalating global health and economic burden. Such
a surge is driven by epidemic prevalence rates of metabolic disorders, such as obesity and …

Dihydromyricetin (DHM) is a natural bioactive flavonoid extracted from Ampelopsis
Grossedentata, a commonly used Chinese herbal medicine. It has multiple beneficial …

Fat deposition is an economically important trait in pigs. Ningxiang pig, one of the four
famous indigenous breeds in China, is characterized by high fat content. The underlying …

Background Disturbance in the differentiation process of bone marrow mesenchymal stem
cells (BMSCs) leads to osteoporosis. Mitochondrial dynamics plays a pivotal role in the …

Background Thermogenic beige adipocytes, which dissipate energy as heat, are found in
neonates and adults. Recent studies show that neonatal beige adipocytes are highly plastic …