During meiosis, a programmed induction of DNA double-strand breaks (DSBs) leads to the
exchange of genetic material between homologous chromosomes. These exchanges …

Cellular senescence is associated with ageing and cancer in vivo and has a proven tumour-
suppressive function. Common to both ageing and cancer is the generation of DNA damage …

Male gametes are generated through a specialised differentiation pathway involving a
series of developmental transitions that are poorly characterised at the molecular level …

In lower eukaryotes, Sir2 serves as a histone deacetylase and is implicated in chromatin
silencing, longevity, and genome stability. Here we mutated the Sirt1 gene, a homolog of …

The epigenetic profile of germ cells, which is defined by modifications of DNA and
chromatin, changes dynamically during their development. Many of the changes are …

Germline mutations of the breast cancer associated gene 1 (BRCA1) predispose women to
breast and ovarian cancers. BRCA1 is a large protein with multiple functional domains and …

X chromosome inactivation is most commonly studied in the context of female mammalian
development, where it performs an essential role in dosage compensation. However …

In the last decade, many papers highlighted that the histone variant H2AX and its
phosphorylation on Ser 139 (γH2AX) cannot be simply considered a specific DNA double …

Meiotic crossovers are produced when programmed double-strand breaks (DSBs) are
repaired by recombination from homologous chromosomes (homologues). In a wide variety …

In meiotic prophase, chromosomes are organized into compacted loop arrays to promote
homolog pairing and recombination. Here, we probe the architecture of the mouse …