Exploring pathological link between antimicrobial and amyloid peptides
Amyloid peptides (AMYs) and antimicrobial peptides (AMPs) are considered as the two
distinct families of peptides, characterized by their unique sequences, structures, biological …
distinct families of peptides, characterized by their unique sequences, structures, biological …
Design principles and fundamental understanding of biosensors for amyloid-β detection
Alzheimer's disease (AD), as an age-related, progressive neurodegenerative disease,
poses substantial challenges and burdens on public health and disease research. While …
poses substantial challenges and burdens on public health and disease research. While …
Tetrameric Aβ40 and Aβ42 β-barrel structures by extensive atomistic simulations. II. In aqueous solution
PH Nguyen, JM Campanera, ST Ngo… - The Journal of …, 2019 - ACS Publications
Alzheimer's disease (AD) is characterized by the accumulation of extracellular Aβ42 and
Aβ40 oligomers and plaques. In a recent computational study, we found that the presence of …
Aβ40 oligomers and plaques. In a recent computational study, we found that the presence of …
Tanshinones inhibit hIAPP aggregation, disaggregate preformed hIAPP fibrils, and protect cultured cells
Misfolding and aggregation of amyloid peptides are the key pathological events in many
neurodegenerative diseases. The development of effective inhibitors and drugs to prevent …
neurodegenerative diseases. The development of effective inhibitors and drugs to prevent …
Interactions between curcumin derivatives and amyloid-β fibrils: insights from molecular dynamics simulations
JM Jakubowski, AA Orr, DA Le… - Journal of chemical …, 2019 - ACS Publications
The aggregation of amyloid-β (Aβ) peptides into senile plaques is a hallmark of Alzheimer's
disease (AD) and is hypothesized to be the primary cause of AD related neurodegeneration …
disease (AD) and is hypothesized to be the primary cause of AD related neurodegeneration …
Nanotechnological approaches for targeting amyloid-β aggregation with potential for neurodegenerative disease therapy and diagnosis
Neurodegenerative disorders can arise as a result of amyloid-β production and misfolding of
its protein. The complex anatomy of the brain and the unresolved mechanics of the central …
its protein. The complex anatomy of the brain and the unresolved mechanics of the central …
Introduction and fundamentals of human islet amyloid polypeptide inhibitors
Type 2 diabetes (T2D) is a common protein misfolding disease (PMD), and its pathogenesis
is considered to be tightly associated with the aggregation of the disease-causative hIAPP …
is considered to be tightly associated with the aggregation of the disease-causative hIAPP …
Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules: mechanistic insights and design rules
S Brahmachari, A Paul, D Segal… - Future medicinal …, 2017 - Taylor & Francis
Protein misfolding and aggregation have been associated with several human disorders,
including Alzheimer's, Parkinson's and Huntington's diseases, as well as senile systemic …
including Alzheimer's, Parkinson's and Huntington's diseases, as well as senile systemic …
Targeting human islet amyloid polypeptide aggregation and toxicity in type 2 diabetes: An overview of peptide-based inhibitors
Type 2 diabetes (T2D) is a chronic metabolic disease characterized by insulin resistance
and a progressive loss of pancreatic islet β-cell mass, which leads to insufficient secretion of …
and a progressive loss of pancreatic islet β-cell mass, which leads to insufficient secretion of …
[HTML][HTML] Atomistic-level study of the interactions between hIAPP protofibrils and membranes: Influence of pH and lipid composition
The pathology of type 2 diabetes mellitus is associated with the aggregation of human islet
amyloid polypeptide (hIAPP) and aggregation-mediated membrane disruption. The …
amyloid polypeptide (hIAPP) and aggregation-mediated membrane disruption. The …