Inositol pyrophosphates as versatile metabolic messengers
Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling
metabolites whose versatile modes of action are being increasingly appreciated. These …
metabolites whose versatile modes of action are being increasingly appreciated. These …
Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling
SB Shears - Journal of cellular physiology, 2018 - Wiley Online Library
Inositol pyrophosphates are small, diffusible signaling molecules that possess the most
concentrated three‐dimensional array of phosphate groups in Nature; up to eight …
concentrated three‐dimensional array of phosphate groups in Nature; up to eight …
Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast
Although many prokaryotes have glycolysis alternatives, it's considered as the only energy-
generating glucose catabolic pathway in eukaryotes. Here, we managed to create a hybrid …
generating glucose catabolic pathway in eukaryotes. Here, we managed to create a hybrid …
The inositol hexakisphosphate kinases IP6K1 and-2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export
Phosphate's central role in most biochemical reactions in a living organism requires
carefully maintained homeostasis. Although phosphate homeostasis in mammals has long …
carefully maintained homeostasis. Although phosphate homeostasis in mammals has long …
[HTML][HTML] Versatile signaling mechanisms of inositol pyrophosphates
MN Trung, D Furkert, D Fiedler - Current opinion in chemical biology, 2022 - Elsevier
Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which
regulate central biological processes in health and disease, such as cellular phosphate and …
regulate central biological processes in health and disease, such as cellular phosphate and …
Phosphate homeostasis− a vital metabolic equilibrium maintained through the INPHORS signaling pathway
S Austin, A Mayer - Frontiers in Microbiology, 2020 - frontiersin.org
Cells face major changes in demand for and supply of inorganic phosphate (Pi). Pi is often a
limiting nutrient in the environment, particularly for plants and microorganisms. At the same …
limiting nutrient in the environment, particularly for plants and microorganisms. At the same …
Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development
F Laurent, SM Bartsch, A Shukla, F Rico-Resendiz… - PLoS …, 2024 - journals.plos.org
Inositol pyrophosphates (PP-InsPs) are nutrient messengers whose cellular levels are
precisely regulated. Diphosphoinositol pentakisphosphate kinases (PPIP5Ks) generate the …
precisely regulated. Diphosphoinositol pentakisphosphate kinases (PPIP5Ks) generate the …
IP8: A quantitatively minor inositol pyrophosphate signaling molecule that punches above its weight
The inositol pyrophosphates (PP-IPs) are specialized members of the wider inositol
phosphate signaling family that possess functionally significant diphosphate groups. The PP …
phosphate signaling family that possess functionally significant diphosphate groups. The PP …
A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop
Structural snapshots of protein/ligand complexes are a prerequisite for gaining atomic level
insight into enzymatic reaction mechanisms. An important group of enzymes has been …
insight into enzymatic reaction mechanisms. An important group of enzymes has been …
Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans
Phosphatases, together with kinases and transcription factors, are key components in
cellular signalling networks. Here, we present a systematic functional analysis of the …
cellular signalling networks. Here, we present a systematic functional analysis of the …