Islet transplantation may be used to treat type I diabetes. Despite tremendous progress in
islet isolation, culture, and preservation, the clinical use of this modality of treatment is …

Pancreatic islets are vital endocrine regulators of systemic metabolism, and recent
investigations have increasingly focused on understanding human islet biology. Studies of …

Many organisms that withstand desiccation express the disaccharide trehalose. We have
now expressed the otsA and otsB genes of Escherichia coli, which encode trehalose …

OBJECTIVE Several clinical studies have shown the benefits of renin-angiotensin system
(RAS) blockade in the development of diabetes, and a local RAS has been identified in …

The nature and even existence of adult pancreatic endocrine stem or progenitor cells is a
subject of controversy in the field of beta-cell replacement for diabetes. One place to search …

The physiological role of soluble N-ethylmaleimide-sensitive factor attachment protein
(SNAP) receptor (SNARE) proteins in insulin exocytosis has been reported in pancreatic …

We exploited the ability of lentiviral vectors to govern the stable transduction of cells
irrespective of their cycling status to induce the reversible immortalization of human primary …

Context.—Mantle cell lymphoma (MCL) is a distinct type of B-cell non-Hodgkin lymphoma
characterized by t (11; 14)(q13; q32) and cyclin D1 overexpression. The pathogenesis of …

Lysophosphatidic acid (LPA) is a naturally occurring phospholipid that activates a variety of
biological activities including cell proliferation. Three mammalian LPA receptor (LPAr) …

Hepatocyte growth factor (HGF) increases beta cell proliferation and function in rat insulin
promoter (RIP)-targeted transgenic mice. RIP-HGF mouse islets also function superiorly to …