Urgency and necessity of Epstein-Barr virus prophylactic vaccines

L Zhong, C Krummenacher, W Zhang, J Hong, Q Feng… - npj Vaccines, 2022 - nature.com
Abstract Epstein-Barr virus (EBV), a γ-herpesvirus, is the first identified oncogenic virus,
which establishes permanent infection in humans. EBV causes infectious mononucleosis …

Immunotherapeutic approaches in EBV-associated nasopharyngeal carcinoma

W Li, X Duan, X Chen, M Zhan, H Peng… - Frontiers in …, 2023 - frontiersin.org
Epstein–Barr virus (EBV) was the first tumor virus in humans. Nasopharyngeal carcinoma
(NPC) accounts for approximately 60% of the 200,000 new tumor cases caused by EBV …

A gB nanoparticle vaccine elicits a protective neutralizing antibody response against EBV

C Sun, YF Kang, XY Fang, YN Liu, GL Bu, AJ Wang… - Cell Host & Microbe, 2023 - cell.com
Epstein-Barr virus (EBV) is a global public health concern, as it is known to cause multiple
diseases while also being etiologically associated with a wide range of epithelial and …

Affinity exploration of SARS-CoV-2 RBD variants to mAb-functionalized plasmonic metasurfaces for label-free immunoassay boosting

F Li, J Hong, C Guan, K Chen, Y Xie, Q Wu, J Chen… - ACS …, 2023 - ACS Publications
Plasmonic metasurfaces (PMs) functionalized with the monoclonal antibody (mAb) are
promising biophotonic sensors for biomolecular interaction analysis and convenient …

Targeting herpesvirus entry complex and fusogen glycoproteins with prophylactic and therapeutic agents

L Zhong, W Zhang, C Krummenacher, Y Chen… - Trends in …, 2023 - cell.com
Herpesviruses are among the most successful viruses found in human populations. They
establish lifelong latent infections, which are punctuated by recurrent reactivations. The entry …

Anti‐EBV antibodies: Roles in diagnosis, pathogenesis, and antiviral therapy

C Xie, LY Zhong, GL Bu, GX Zhao… - Journal of Medical …, 2023 - Wiley Online Library
Epstein‐Barr virus (EBV) infection is prevalent in global population and associated with
multiple malignancies and autoimmune diseases. During the infection, EBV‐harbored or …

Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells

W Bu, A Kumar, NL Board, JH Kim, K Dowdell, S Zhang… - Immunity, 2024 - cell.com
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with B cell
lymphomas. EBV glycoprotein 42 (gp42) binds HLA class II and activates membrane fusion …

Antibody and Cell-Based Therapies against Virus-Induced Cancers in the Context of HIV/AIDS

J Joseph, G Sandel, R Kulkarni, R Alatrash, BB Herrera… - Pathogens, 2023 - mdpi.com
Infectious agents, notably viruses, can cause or increase the risk of cancer occurrences.
These agents often disrupt normal cellular functions, promote uncontrolled proliferation and …

Structures of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus virions reveal species-specific tegument and envelope features

J Zhen, J Chen, H Huang, S Liao, S Liu, Y Yuan… - Journal of …, 2024 - journals.asm.org
Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are
classified into the gammaherpesvirus subfamily of Herpesviridae, which stands out from its …

Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection

J Hong, L Zhong, L Liu, Q Wu, W Zhang, K Chen… - Cell Reports …, 2023 - cell.com
Epstein-Barr virus (EBV) is closely associated with cancer, multiple sclerosis, and post-acute
coronavirus disease 2019 (COVID-19) sequelae. There are currently no approved …