Infectious diseases caused by pathogens including viruses, bacteria, fungi, and parasites
are ranked as the second leading cause of death worldwide by the World Health …

Abstract γδ T cells remain an enigma. They are capable of generating more unique antigen
receptors than αβ T cells and B cells combined, yet their repertoire of antigen receptors is …

Reactivation of latent tuberculosis contributes significantly to the incidence of disease
caused by Mycobacterium tuberculosis. The mechanisms involved in the containment of …

Allogeneic stem cell transplantation (ASCT) has improved leukemia-free survival (LFS) in
many but not all patients with acute leukemia. This is an eight-year follow-up to our previous …

Chimeric antigen receptor (CAR) T cell therapy has been successful in treating B cell
malignancies in clinical trials; however, fewer studies have evaluated CAR T cell therapy for …

Mycobacterium ulcerans is the causative agent of Buruli ulcer, a tropical ulcerative skin
disease. One of the most intriguing aspects of this disease is the presence of extensive …

Tuberculosis remains today one of the top three fatal infectious diseases, together with
acquired immune deficiency syndrome (AIDS) and malaria. During the last decade, 90 …

Recent advances in the characterization of the protective immune response to mycobacteria
have highlighted the central role of phenotypically and functionally distinct subsets of T cells …

Background: Breakdown of tolerance against the commensal microflora is believed to be a
major factor in the pathogenesis of inflammatory bowel disease (IBD). Dendritic cells (DC) …

Down-regulation of expression of MHC alleles, as well as tumor-specific antigens, is
observed frequently during tumor progression, resulting in an impairment of MHC-restricted …