The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

Antimicrobial resistance to virtually all clinically applied antibiotic classes severely limits the
available options to treat bacterial infections. Hence, there is an urgent need to develop and …

Despite the central role of division in bacterial physiology, how division proteins work
together as a nanoscale machine to divide the cell remains poorly understood. Cell division …

Bacterial cell division in many organisms involves a constricting cytokinetic ring that is
orchestrated by the tubulin-like protein FtsZ. FtsZ forms dynamic filaments close to the …

Salmonella Typhi is emerging as a drug-resistant pathogen, particularly in developing
countries. Hence, the progressive development of new antibiotics against novel drug targets …

Widespread antimicrobial resistance among bacterial pathogens is a serious threat to public
health. Thus, identification of new targets and development of new antibacterial agents are …

Treadmilling protein filaments perform essential cellular functions by growing from one end
while shrinking from the other, driven by nucleotide hydrolysis. Bacterial cell division relies …

The global spread of bacterial antimicrobial resistance is associated to millions of deaths
from bacterial infections per year, many of which were previously treatable. This, combined …

Combating anti-microbial resistance by developing alternative strategies is the need of the
hour. Cell division, particularly FtsZ, is being extensively studied for its potential as an …

In the effort to combat antibiotic resistance, inhibitors of the essential bacterial protein FtsZ
have emerged as a promising new class of compounds with clinical potential. One such FtsZ …