Gene therapy is an emerging and promising strategy in cancer therapy where small
interfering RNA (siRNA) system has been deployed for down-regulation of targeted gene …

RNA-based therapies, and siRNAs in particular, have attractive therapeutic potential for
cancer treatment due to their ability to silence genes that are imperative for tumor …

Intracellular delivery of messenger RNA (mRNA) has the potential to induce protein
production for many therapeutic applications. Although lipid nanoparticles have shown …

Extracellular vesicles (EVs), including exosomes and microvesicles, have emerged as
promising drug delivery vehicles for small RNAs (siRNA and miRNA) due to their natural …

In the past decade, nucleic acid‐based drugs have emerged as an extremely promising
approach for silencing specific disease‐related genes and targeting undruggable ones …

Liver diseases, particularly viral hepatitis, cirrhosis and hepatocellular carcinoma, are
common in clinical practice with high morbidity and mortality worldwide. Many substances …

A significant challenge in the development of clinically viable siRNA delivery systems is a
lack of in vitro–in vivo translatability: many delivery vehicles that are initially promising in cell …

Purpose Resistance to chemotherapeutic agents such as doxorubicin is a major reason for
cancer treatment failure. At present the treatment option for metastatic breast cancer is very …

The efforts made to develop RNAi‐based therapies have led to productive research in the
field of infections in humans, such as hepatitis C virus (HCV), hepatitis B virus (HBV), human …

Sustained antiviral responses of chronic hepatitis C virus (HCV) infection have improved
recently by the use of direct-acting antiviral agents along with interferon (IFN)-α and ribavirin …