The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an annually
updated evidence-based strategy for asthma management and prevention, which can be …

Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …

Importance Severe asthma exacerbations cause significant morbidity and costs. Whether
vitamin D 3 supplementation reduces severe childhood asthma exacerbations is unclear …

Importance The house dust mite (HDM) sublingual allergen immunotherapy (SLIT) tablet is a
potential novel treatment option for HDM allergy–related asthma. Objectives To evaluate the …

The selection of appropriate outcomes or domains is crucial when designing clinical trials in
order to compare directly the effects of different interventions in ways that minimize bias. If …

Importance The benefits and harms of adding long-acting muscarinic antagonists (LAMAs)
to inhaled corticosteroids (ICS) and long-acting β 2-agonists (LABAs) for moderate to severe …

Background and objective Little is known about how comorbidities affect difficult asthma
patients across different domains of asthma outcomes. We hypothesized that comorbidities …

Background. In clinical practice, patients whose airway disease shares features of both
asthma and chronic obstructive pulmonary disease (COPD) remain poorly recognized …

Acute asthma remains an important medical emergency, the most frequent cause of acute
admissions in children and a major source of morbidity for adults with asthma. In all ages …

Background Recent efficacy studies of asthma biologics have included highly enriched
patient populations. Using a similar approach, we examined factors that predict response to …