Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Research on the role of reactive oxygen species (ROS) in the aging process has advanced
significantly over the last two decades. In light of recent findings, ROS takes part in the aging …

An increasing interest in a healthy lifestyle raises questions about optimal body weight.
Evidently, it should be clearly discriminated between the standardised “normal” body weight …

Decades of advancements in immuno-oncology have enabled the development of current
immunotherapies, which provide long-term treatment responses in certain metastatic cancer …

Embryonic development is characterized by rapidly dividing cells, cellular plasticity and a
highly vascular microenvironment. These features are similar to those of tumour tissue, in …

Brain metastases is the most common intracranial tumor and account for approximately 20%
of all systematic cancer cases. It is a leading cause of death in advanced-stage cancer …

Most solid cancer-related deaths result from metastasis, a multistep process in which cancer
cells exit the primary site, intravasate into the bloodstream, extravasate, and colonize distant …

Due to the reactive medical approach applied to disease management, stroke has reached
an epidemic scale worldwide. In 2019, the global stroke prevalence was 101.5 million …

Metastasis, a primary cause of death in patients with malignancies, is promoted by intrinsic
changes in both tumor and non-malignant cells in the tumor microenvironment (TME). As …