Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

Age-related chronic diseases are an enormous burden to modern societies worldwide.
Among these, osteoporosis, a condition that predisposes individuals to an increased risk of …

Osteoarthritis (OA) is a chronic degenerative disease afflicting millions globally. Despite the
development of numerous pharmacological treatments for OA, a substantial unmet need for …

Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a
range of cell types, including osteoblasts, chondrocytes, myocytes, and adipocytes. Multiple …

Bone marrow adipocytes (BMAds) affect bone homeostasis, but the mechanism remains
unclear. Here, we showed that exercise inhibited PCNA clamp-associated factor (PCLAF) …

Introduction: Longitudinal effect of diet-induced obesity on bone is uncertain. Prior work
showed both no effect and a decrement in bone density or quality when obesity begins prior …

Osteoarthritis (OA), a chronic degenerative joint disease, is highly prevalent among the
aging population, and often leads to joint pain, disability, and a diminished quality of life …

Objective For identification of aberrantly expressed genes in mesenchymal stem cells of
osteoporosis (OP) and osteoarthritis (OA), Gene Expression Omnibus (GEO) datasets were …

Mesenchymal stem cells (MSCs) play an essential role in multiple physiological processes
in vivo and a promising cell-based therapy for various diseases. Nonetheless, MSCs suffer …

Biological aging profoundly impairs the homeostasis of the skeletal system. Cellular
senescence, a hallmark of biological aging, plays an instrumental role in bone disease. The …