Protein motion in the nucleus: from anomalous diffusion to weak interactions

M Woringer, X Darzacq - Biochemical Society Transactions, 2018 - portlandpress.com
Understanding how transcription factors (TFs) regulate mammalian gene expression in
space and time is a central topic in biology. To activate a gene, a TF has first to diffuse in the …

PHi-C: deciphering Hi-C data into polymer dynamics

S Shinkai, M Nakagawa, T Sugawara… - NAR genomics and …, 2020 - academic.oup.com
Genomes are spatiotemporally organized within the cell nucleus. Genome-wide
chromosome conformation capture (Hi-C) technologies have uncovered the 3D genome …

Chromatin organization and behavior in HRAS-transformed mouse fibroblasts

A Otsuka, K Minami, K Higashi, A Kawaguchi… - Chromosoma, 2024 - Springer
In higher eukaryotic cells, a string of nucleosomes, where long genomic DNA is wrapped
around core histones, are rather irregularly folded into a number of condensed chromatin …

Toward understanding the dynamic state of 3D genome

S Shinkai, S Onami, R Nakato - Computational and Structural …, 2020 - Elsevier
Abstract The three-dimensional (3D) genome organization and its role in biological activities
have been investigated for over a decade in the field of cell biology. Recent studies using …

ヌクレオームコンソーシアム

田代聡, 木村宏 - 生物物理, 2018 - jstage.jst.go.jp
研究内容: 細胞核構造, ゲノム修復機構連絡先:〒 734-8553 広島市南区霞 1-2-3 E-mail:
ktashiro@ hiroshima-u. ac. jp URL: http://home. hiroshima-u. ac. jp/cellbio/木村 宏 (きむら …