Comprehensive exploration of Biochanin A as an oncotherapeutics potential in the treatment of multivarious cancers with molecular insights

M Sohel - Phytotherapy Research, 2024 - Wiley Online Library
Cancer is considered a leading cause of mortality. This rising cancer death rate and several
existing limitations like side effects, poor efficacies, and high cost of the present …

Hypoxic effects on matrix metalloproteinases' expression in the tumor microenvironment and therapeutic perspectives

G Gonzalez-Avila, B Sommer, E Flores-Soto… - International Journal of …, 2023 - mdpi.com
The tumor microenvironment (TME) is characterized by an acidic pH and low oxygen
concentrations. Hypoxia induces neoplastic cell evasion of the immune surveillance, rapid …

Glycolysis, The Sweet Appetite of the Tumour Microenvironment

Z Kooshan, L Cárdenas-Piedra, J Clements, J Batra - Cancer Letters, 2024 - Elsevier
Cancer cells display an altered metabolic phenotype, characterised by increased glycolysis
and lactate production, even in the presence of sufficient oxygen-a phenomenon known as …

[HTML][HTML] Antibacterial, Antifungal, Antiviral Activity, and Mechanisms of Action of Plant Polyphenols

S Davidova, AS Galabov, G Satchanska - Microorganisms, 2024 - mdpi.com
This review describes the enhanced classification of polyphenols into flavonoids, lignans,
phenolic acids, stilbenes, and tannins. Its focus is the natural sources of polyphenols and an …

[HTML][HTML] Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer

J Li, D Zhang, S Wang, P Yu, J Sun, Y Zhang… - Journal of Advanced …, 2024 - Elsevier
Introduction Baicalein, a bioactive component of Scutellaria baicalensis Georgi, has been
shown to promote apoptosis in non-small cell lung cancer cells. However, previous studies …

Phytochemical‐mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach

M Al Azzani, ZN Nizami, R Magramane… - Phytotherapy …, 2024 - Wiley Online Library
Autophagy and endoplasmic reticulum (ER) stress are conserved processes that generally
promote survival, but can induce cell death when physiological thresholds are crossed. The …

Therapeutic targeting of MOAP-1 in cancer: A systematic review of current approaches and future directions

X Koong, K Look, ADI Abdullah, KO Tan… - Progress In Microbes …, 2023 - hh-publisher.com
Abstract The Modulator of Apoptosis 1 (MOAP-1) protein, a crucial regulator of apoptosis,
has recently attracted considerable interest in oncology research. Its potential as a …

Temporal progression of aortic valve pathogenesis in a mouse model of osteogenesis imperfecta

K Thatcher, CR Mattern, D Chaparro, V Goveas… - Journal of …, 2023 - mdpi.com
Organization of extracellular matrix (ECM) components, including collagens, proteoglycans,
and elastin, is essential for maintaining the structure and function of heart valves throughout …

State of the art of pharmacological activators of p53 in ocular malignancies

F Casciano, E Zauli, M Busin, L Caruso, S AlMesfer… - Cancers, 2023 - mdpi.com
Simple Summary Ocular malignancies encompass a broad range of disorders that affect the
eyelids, orbit, and eye and have significant impacts for national healthcare systems. Due to …

Preparation of biomimetic selenium–baicalein nanoparticles and their targeted therapeutic application in nonsmall cell lung cancer

H Shi, B Wang, H Ma, Y Li, J Du, B Zhang… - Molecular …, 2024 - ACS Publications
In this study, we prepared bionic selenium–baicalein nanoparticles (ACM-SSe–BE) for the
targeted treatment of nonsmall cell lung cancer. Due to the coating of the A549 membrane …