Background Nutraceuticals exist in a legal limbo and the existing legislative efforts remain
confusing, complex and not harmonized throughout the many regions of the Globe. These …

Background Zeaxanthin is a natural xanthophyll carotenoid that is widely produced by
plants, algae and microorganisms and plays a critical role in the prevention of age-related …

Aging may significantly modify antioxidant and photoprotective properties of melanin in
retinal pigment epithelium (RPE). Here, photoreactivity of melanosomes (MS), isolated from …

The risk of chronic oxidative stress in the retinal pigment epithelium (RPE) increases with
age due to accumulation of the photoreactive age pigment lipofuscin (LFG). Here, we asked …

Endoplasmic reticulum (ER) stress-mediated apoptosis is a well-known factor in the
pathogenesis of age-related macular degeneration (AMD). ER stress leads to accumulation …

Curcumin is a plant‐derived yellow‐orange compound widely used as a spice, dye and food
additive. It is also believed to have therapeutic effects against different disorders. On the …

Although the primary biological function of retina photoreceptors is to absorb light and
provide visual nformation, exposure to intense light could increase the risk of phototoxic …

Macular xanthophylls (MXs) are distinguished from other dietary carotenoids by their high
membrane solubility and preferential transmembrane orientation. Additionally, these …

Retinal lipofuscin accumulates with age in the retinal pigment epithelium (RPE), where its
fluorescence properties are used to assess retinal health. It was observed that there is a …

One of the most prominent age-related changes of retinal pigment epithelium (RPE) is the
accumulation of melanolipofuscin granules, which could contribute to oxidative stress in the …