A role for the cerebellum in causing ataxia, a disorder characterized by uncoordinated
movement, is widely accepted. Recent work has suggested that alterations in activity …

Dystonias comprise a group of movement disorders that are characterized by involuntary
movements and postures. Insight into the nature of neuronal dysfunction has been provided …

An enigmatic feature of many genetic diseases is that mutations in widely expressed genes
cause tissue-specific illness. One example is DYT1 dystonia, a neurodevelopmental disease …

Much research has implicated the striatum in motor learning, but the underlying mechanisms
have not been identified. Although NMDA receptor (NMDAR)-dependent long-term …

Dystonia is a movement disorder of both genetic and non-genetic causes, which typically
results in twisted posturing due to abnormal muscle contraction. Evidence from dystonia …

To date, clinical trials have failed to find an effective therapy for victims of traumatic brain
injury (TBI) who live with motor, cognitive, and psychiatric complaints. Pre-clinical …

Lack of a preclinical model of primary dystonia that exhibits dystonic-like twisting movements
has stymied identification of the cellular and molecular underpinnings of the disease. The …

Presently, 17 distinct monogenic primary dystonias referred to as dystonias 1–4, 5a, b, 6–8,
10–13 and 15–18 (loci DYT 1–4, 5a, b, 6–8, 10–13, 15–18) have been recognized. Twelve …

In eukaryotes, the function of the cell's nucleus has primarily been considered to be the
repository for the organism's genome. However, this rather simplistic view is undergoing a …

DYT1 is a debilitating movement disorder caused by loss-of-function mutations in torsinA.
How these mutations cause dystonia remains unknown. Mouse models which have …