Recent Advances in enhancer of zeste homolog 2 Inhibitors: Structural insights and therapeutic applications
R Cao, J Ni, X Zhang, M Qi, Z Zhang, Z Liu, G Chen - Bioorganic Chemistry, 2024 - Elsevier
Abstract Enhancer of Zeste Homolog 2 (EZH2) is overexpressed in many malignancies and
plays a critical role in cancer progression. Therefore, it is considered a promising target for …
plays a critical role in cancer progression. Therefore, it is considered a promising target for …
[HTML][HTML] Advancements in Multiple Myeloma Research: High-Throughput Sequencing Technologies, Omics, and the Role of Artificial Intelligence
A Gutiérrez-González, I Del Hierro… - Biology, 2024 - mdpi.com
Multiple myeloma is a complex and challenging type of blood cancer that affects plasma
cells in the bone marrow. In recent years, the development of advanced research …
cells in the bone marrow. In recent years, the development of advanced research …
Pharmacophore derived 3D-QSAR, molecular docking, and simulation studies of quinoxaline derivatives as ALR2 inhibitors
Abstract Aldose Reductase 2 (ALR2), a key enzyme of the polyol pathway, plays a crucial
role in the pathogenesis of diabetic complications. Quinoxaline scaffold-based compounds …
role in the pathogenesis of diabetic complications. Quinoxaline scaffold-based compounds …
Study on the effect of Ezh2 inhibitor combined with tigit monoclonal antibody against multiple myeloma cells
Z Liu, Y Jia, C Yang, H Liu, H Shen, H Wang… - International Journal of …, 2023 - mdpi.com
EZH2, a member of the polycomb repressive complex 2, induces trimethylation of the
downstream gene at the histone three lysine 27 (H3K27me3) position to inhibit tumor cell …
downstream gene at the histone three lysine 27 (H3K27me3) position to inhibit tumor cell …