Genome-wide association studies of cancer: current insights and future perspectives
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
The expanding landscape of alternative splicing variation in human populations
Alternative splicing is a tightly regulated biological process by which the number of gene
products for any given gene can be greatly expanded. Genomic variants in splicing …
products for any given gene can be greatly expanded. Genomic variants in splicing …
Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy
JG Lohr, P Stojanov, SL Carter, P Cruz-Gordillo… - Cancer cell, 2014 - cell.com
We performed massively parallel sequencing of paired tumor/normal samples from 203
multiple myeloma (MM) patients and identified significantly mutated genes and copy number …
multiple myeloma (MM) patients and identified significantly mutated genes and copy number …
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma
Multiple myeloma is an incurable plasma cell malignancy with a complex and incompletely
understood molecular pathogenesis. Here we use whole-exome sequencing, copy-number …
understood molecular pathogenesis. Here we use whole-exome sequencing, copy-number …
The molecular pathogenesis of chronic lymphocytic leukaemia
G Fabbri, R Dalla-Favera - Nature Reviews Cancer, 2016 - nature.com
Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …
Chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) is a malignancy of CD5+ B cells that is characterized
by the accumulation of small, mature-appearing lymphocytes in the blood, marrow and …
by the accumulation of small, mature-appearing lymphocytes in the blood, marrow and …
Monoclonal B-cell lymphocytosis and early-stage chronic lymphocytic leukemia: diagnosis, natural history, and risk stratification
P Strati, TD Shanafelt - Blood, The Journal of the American …, 2015 - ashpublications.org
Monoclonal B lymphocytosis (MBL) is defined as the presence of a clonal B-cell population
in the peripheral blood with fewer than 5× 109/L B-cells and no other signs of a …
in the peripheral blood with fewer than 5× 109/L B-cells and no other signs of a …
Chronic lymphocytic leukaemia
L Scarfò, AJM Ferreri, P Ghia - Critical reviews in oncology/hematology, 2016 - Elsevier
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among the adults in
the Western World. CLL (and the corresponding nodal entity small lymphocytic lymphoma …
the Western World. CLL (and the corresponding nodal entity small lymphocytic lymphoma …
Mapping complex disease traits with global gene expression
Variation in gene expression is an important mechanism underlying susceptibility to
complex disease. The simultaneous genome-wide assay of gene expression and genetic …
complex disease. The simultaneous genome-wide assay of gene expression and genetic …
From pathogenesis to treatment of chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) has several unique features that distinguish it from
other cancers. Most CLL tumour cells are inert and arrested in G0/G1 of the cell cycle and …
other cancers. Most CLL tumour cells are inert and arrested in G0/G1 of the cell cycle and …