Histone lysine methylation has emerged as a critical player in the regulation of gene
expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a …

The power of any genetic model organism is derived, in part, from the ease with which gene
expression can be manipulated. The short generation time and invariant developmental …

The three-dimensional organization of a genome plays a critical role in regulating gene
expression, yet little is known about the machinery and mechanisms that determine higher …

Genome function is dynamically regulated in part by chromatin, which consists of the
histones, non-histone proteins and RNA molecules that package DNA. Studies in …

We systematically generated large-scale data sets to improve genome annotation for the
nematode Caenorhabditis elegans, a key model organism. These data sets include …

Chromatin modifiers regulate lifespan in several organisms, raising the question of whether
changes in chromatin states in the parental generation could be incompletely …

Post‐translational modification of histones and DNA methylation are important components
of chromatin‐level control of genome activity in eukaryotes. However, principles governing …

Chromatin modifications are associated with many aspects of gene expression, yet their role
in cellular transitions during development remains elusive. Here, we use a new approach to …

Although genomes are defined by their sequence, the linear arrangement of nucleotides is
only their most basic feature. A fundamental property of genomes is their topological …

The factors that sequester transcriptionally repressed heterochromatin at the nuclear
periphery are currently unknown. In a genome-wide RNAi screen, we found that depletion of …