The liver as an endocrine organ—linking NAFLD and insulin resistance

MJ Watt, PM Miotto, W De Nardo… - Endocrine …, 2019 - academic.oup.com
The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …

[HTML][HTML] Diabetes as a risk factor for MASH progression

S Gancheva, M Roden, L Castera - Diabetes Research and Clinical …, 2024 - Elsevier
Abstract Non-alcoholic (now: metabolic) steatohepatitis (MASH) is the progressive
inflammatory form of metabolic dysfunction-associated steatotic liver disease (MASLD) …

Liver-derived extracellular vesicles improve whole-body glycaemic control via inter-organ communication

PM Miotto, CH Yang, SN Keenan, W De Nardo… - Nature …, 2024 - nature.com
Small extracellular vesicles (EVs) are signalling messengers that regulate inter-tissue
communication through delivery of their molecular cargo. Here, we show that liver-derived …

Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration

JS Pedersen, MO Rygg, K Chrøis, EG Sustarsic… - Nature …, 2022 - nature.com
Impaired mitochondrial oxidative phosphorylation (OXPHOS) in liver tissue has been
hypothesised to contribute to the development of nonalcoholic steatohepatitis in patients …

Bariatric surgery is associated with decreased progression of nonalcoholic fatty liver disease to cirrhosis: a retrospective cohort analysis

KM Wirth, AC Sheka, S Kizy, R Irey, A Benner… - Annals of …, 2020 - journals.lww.com
Objective: This study sought to compare trends in the development of cirrhosis between
patients with NAFLD who underwent bariatric surgery and a well-matched group of …

Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control

MK Montgomery, J Bayliss, S Nie, W De Nardo… - Nature …, 2022 - nature.com
Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, yet the
pathophysiological mechanisms underpinning this bidirectional relationship remain …

Treatment with cinnamaldehyde reduces the visceral adiposity and regulates lipid metabolism, autophagy and endoplasmic reticulum stress in the liver of a rat model …

JGO Neto, SK Boechat, JS Romão… - The Journal of nutritional …, 2020 - Elsevier
Nutrition at early stages of life contributes to the alarming incidence of childhood obesity,
insulin resistance and hepatoesteatosis. Cinnamaldehyde, major component of cinnamon …

Mouse strain-dependent variation in metabolic associated fatty liver disease (MAFLD): a comprehensive resource tool for pre-clinical studies

H Karimkhanloo, SN Keenan, J Bayliss, W De Nardo… - Scientific reports, 2023 - nature.com
Abstract Non-alcoholic steatohepatitis (NASH), characterized as the joint presence of
steatosis, hepatocellular ballooning and lobular inflammation, and liver fibrosis are strong …

Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease

A Hussain, P Vasas, ELH Shamsi - Metabolism, 2020 - ncbi.nlm.nih.gov
We read with interest the article by K· I Zheng et al.[1], we congratulate the authors for their
work and conclusions. Although the definition of obesity in this article is slightly different from …

[HTML][HTML] Growing burden of nonalcoholic fatty liver disease in Turkey: A single-center experience

Y Yılmaz, HT Kanı, CÖ Demirtaş, E Kaya… - The Turkish Journal …, 2019 - ncbi.nlm.nih.gov
Materials and Methods This is a retrospective analysis of prospectively collected data from a
total of 468 patients (224 males, 244 females; median age, 47 [18–71]. The study cohort …