[HTML][HTML] Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018–2021)

A Dhiman, R Sharma, RK Singh - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Cancer, which is the uncontrolled growth of cells, is the second leading cause of death after
heart disease. Targeting drugs, especially to specific genes and proteins involved in growth …

The importance of indole and azaindole scaffold in the development of antitumor agents

Y Han, W Dong, Q Guo, X Li, L Huang - European journal of medicinal …, 2020 - Elsevier
With some indoles and azaindoles being successfully developed as anticancer drugs, the
design and synthesis of indole and azaindole derivatives with remarkable antitumor activity …

Current scenario of 1, 3-oxazole derivatives for anticancer activity

X Yan, J Wen, L Zhou, L Fan… - Current Topics in …, 2020 - ingentaconnect.com
Cancer, which has been cursed for human beings for long time is considered as one of the
leading causes of morbidity and mortality across the world. In spite of different types of …

Alkaloids as additional weapons in the fight against breast cancer: A review

Chahat, KT Jha, R Bhatia… - Current Medicinal …, 2024 - benthamdirect.com
Breast carcinoma is among the most frequent cancerous tumour in females around the
globe. The major modalities now employed in the therapeutic management of breast cancer …

Recent developments in oxazole derivatives as anticancer agents: Review on synthetic strategies, mechanism of action and SAR studies

S Kulkarni, K Kaur, V Jaitak - Anti-Cancer Agents in Medicinal …, 2022 - ingentaconnect.com
Background: Cancer is the world's third deadliest disease. Despite the availability of
numerous treatments, researchers are focusing on the development of new drugs with no …

Recent advances in the green synthesis of indole and its derivatives using microwave irradiation and the role of indole moiety in cancer

FA Almalki, AO Baryyan - Green Chemistry Letters and Reviews, 2024 - Taylor & Francis
Indole moiety is widely present in several natural bioactive products and medicinally
important compounds. It is an essential scaffold for the development of novel leads …

Fused pyrrolo-pyridines and pyrrolo-(iso) quinoline<? index value=" pyrrolo-(iso) quinoline"?> as anticancer<? index value=" anticancer"?> agents

D Amariucai-Mantu, V Antoci, MC Sardaru… - Physical Sciences …, 2023 - degruyter.com
This work emphasizes the synthesis strategies and antiproliferative<? index value="
antiproliferative"?> related properties of fused pyrrolo-pyridine<? index value=" pyrrolo …

Pyrrole‐based EGFR inhibitors for the treatment of NCSLC: Binding modes and SARs investigations

J He, L Luo, S Xu, F Yang, W Zhu - Chemical Biology & Drug …, 2023 - Wiley Online Library
The treatment of advanced non‐small cell lung cancer (NSCLC) has made substantial
progress due to the rapid development of small molecule targeted therapy, with dramatically …

Ag (I)-NHC/TBHP promoted aqueous synthesis of some new quinoline-aromatic amides; Anti-proliferative, Anti-VEGFR-2 and Molecular docking studies

M Bangaru, SK Nukala, M Azam, SI Al-Resayes… - Journal of Molecular …, 2024 - Elsevier
Herein, we synthesized some new quinoline-aromatic amides (5a-5o) as VEGFR-2 targeting
anti-proliferative agents via Ag (I)-NHC/TBHP promoted oxidative amidation of 4-(((quinolin …

IMesCuCl/TBHP system for aqueous oxidative amidation: Synthesis of new amide derivatives as EGFR targeting anti-breast cancer agents and computational studies

RR Sagam, M Azam, SI Al-Resayes, D Banothu… - Journal of Molecular …, 2024 - Elsevier
A base free and aqueous synthesis of some new 1, 4-benzoxazinone-tetrazole containing
amides via tert‑butyl hydroperoxide (TBHP) mediated oxidative coupling of 2-(5-(2-(3-oxo-2 …