The actin cytoskeleton—a collection of actin filaments with their accessory and regulatory
proteins—is the primary force-generating machinery in the cell. It can produce pushing …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

The gram-positive bacterium Listeria monocytogenes is the causative agent of listeriosis, a
highly fatal opportunistic foodborne infection. Pregnant women, neonates, the elderly, and …

The Arp2/3 complex is a stable assembly of seven protein subunits including two actin-
related proteins (Arp2 and Arp3) and five novel proteins. Previous work showed that this …

▪ Abstract We review how motile cells regulate actin filament assembly at their leading edge.
Activation of cell surface receptors generates signals (including activated Rho family …

The cellular functions of the actin cytoskeleton require precise regulation of both the
initiation of actin polymerization and the organization of the resulting filaments. The actin …

Although small GTP-binding proteins of the Rho family have been implicated in signaling to
the actin cytoskeleton, the exact nature of the linkage has remained obscure. We describe a …

The leading edge (∼ 1 μm) of lamellipodia in Xenopus laevis keratocytes and fibroblasts
was shown to have an extensively branched organization of actin filaments, which we term …

Lamellipodia, filopodia and membrane ruffles are essential for cell motility, the organization
of membrane domains, phagocytosis and the development of substrate adhesions. Their …

The process of engulfing a foreign particle–phagocytosis–is of fundamental importance for a
wide diversity of organisms. From simple unicellular organisms that use phagocytosis to …