The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Aims Diabetic peripheral neuropathy (DPN) occurs in about half of people with diabetes, of
whom a quarter may develop chronic pain. Pain may remain for years yet be difficult to treat …

Apoptosis, overload Ca 2+ entry and oxidative stress are induced in neurons by hypoxia.
Drug-resistant cancer cells are killed by hypoxic conditions. α-Lipoic acid (ALA) has …

Complex regional pain syndrome type I (CRPS-I) is characterized by intractable chronic
pain. Poor understanding of the underlying mechanisms of CRPS-I accounts for the current …

Vascular cognitive impairment (VCI) refers to cognitive alterations caused by vascular
disease, which is associated with various types of dementia. Because chronic cerebral …

Transient receptor potential (TRP) family proteins form tetrameric nonselective cation
channels. Upon activation, TRP channels depolarize the membrane potential, which can …

Mammalian transient receptor potential ankyrin 1 (TRPA1) is a polymodal nociceptor that
plays an important role in pain generation, but its role as a cold nociceptor is still …

Receptor-type ion channels are critical for detection of noxious stimuli in primary sensory
neurons. Transient receptor potential (TRP) channels mediate pain sensations and promote …

Chemotherapy-induced peripheral neuropathy (CIPN), characterized by symptoms of
paresthesia, dysesthesia, numbness, and pain, is a common adverse effect of several …

Chemotherapy-induced peripheral neuropathy (CIPN) is a severe dose-limiting side effect of
taxanes such as paclitaxel and docetaxel. Despite the high medical needs, insufficient …