Advances in single-cell omics and multiomics for high-resolution molecular profiling
J Lim, C Park, M Kim, H Kim, J Kim… - Experimental & Molecular …, 2024 - nature.com
Single-cell omics technologies have revolutionized molecular profiling by providing high-
resolution insights into cellular heterogeneity and complexity. Traditional bulk omics …
resolution insights into cellular heterogeneity and complexity. Traditional bulk omics …
High-throughput robust single-cell DNA methylation profiling with sciMETv2
DNA methylation is a key epigenetic property that drives gene regulatory programs in
development and disease. Current single-cell methods that produce high quality …
development and disease. Current single-cell methods that produce high quality …
sciMET-cap: high-throughput single-cell methylation analysis with a reduced sequencing burden
SN Acharya, RV Nichols, LE Rylaarsdam… - Genome biology, 2024 - Springer
DNA methylation is a key component of the mammalian epigenome, playing a regulatory
role in development, disease, and other processes. Robust, high-throughput single-cell DNA …
role in development, disease, and other processes. Robust, high-throughput single-cell DNA …
[HTML][HTML] Impact of heat and cold shock on epigenetics and chromatin structure
Cells are continuously exposed to various sources of insults, among which temperature
variations are extremely common. Epigenetic mechanisms, critical players in gene …
variations are extremely common. Epigenetic mechanisms, critical players in gene …
Paternal aging impacts expression and epigenetic markers as early as the first embryonic tissue lineage differentiation
MM Denomme, BR McCallie, ME Haywood, JC Parks… - Human Genomics, 2024 - Springer
Background Advanced paternal age (APA) is associated with adverse outcomes to offspring
health, including increased risk for neurodevelopmental disorders. The aim of this study was …
health, including increased risk for neurodevelopmental disorders. The aim of this study was …
In situ sequence-specific visualization of single methylated cytosine on tissue sections using ICON probe and rolling-circle amplification
S Kitazawa, R Haraguchi, Y Takaoka… - Histochemistry and Cell …, 2023 - Springer
Since epigenetic modifications differ from cell to cell, detecting the DNA methylation status of
individual cells is requisite. Therefore, it is important to conduct “morphology-based …
individual cells is requisite. Therefore, it is important to conduct “morphology-based …