Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies
In recent years, technical developments in mouse genetics and imaging equipment have
substantially advanced our understanding of hematopoietic stem cells (HSCs) and their …
substantially advanced our understanding of hematopoietic stem cells (HSCs) and their …
Sites of Cre‐recombinase activity in mouse lines targeting skeletal cells
ABSTRACT The Cre/Lox system is a powerful tool in the biologist's toolbox, allowing loss‐of‐
function and gain‐of‐function studies, as well as lineage tracing, through gene …
function and gain‐of‐function studies, as well as lineage tracing, through gene …
STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis
S Zhou, Q Dai, X Huang, A Jin, Y Yang, X Gong… - Nature …, 2021 - nature.com
Skeletal deformities are typical AD-HIES manifestations, which are mainly caused by
heterozygous and loss-of-function mutations in Signal transducer and activator of …
heterozygous and loss-of-function mutations in Signal transducer and activator of …
Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation
S Lotinun, R Kiviranta, T Matsubara… - The Journal of …, 2013 - Am Soc Clin Investig
Cathepsin K (CTSK) is secreted by osteoclasts to degrade collagen and other matrix
proteins during bone resorption. Global deletion of Ctsk in mice decreases bone resorption …
proteins during bone resorption. Global deletion of Ctsk in mice decreases bone resorption …
Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual
The detection of estrogen receptor-α (ERα) in osteoblasts and osteoclasts over 20 years ago
suggested that direct effects of estrogens on both of these cell types are responsible for their …
suggested that direct effects of estrogens on both of these cell types are responsible for their …
FOXOs attenuate bone formation by suppressing Wnt signaling
S Iyer, E Ambrogini, SM Bartell, L Han… - The Journal of …, 2013 - Am Soc Clin Investig
Wnt/β-catenin/TCF signaling stimulates bone formation and suppresses adipogenesis. The
hallmarks of skeletal involution with age, on the other hand, are decreased bone formation …
hallmarks of skeletal involution with age, on the other hand, are decreased bone formation …
Osx-Cre Targets Multiple Cell Types besides Osteoblast Lineage in Postnatal Mice
Osterix (Osx or Sp7) is a zinc-finger-family transcriptional factor essential for osteoblast
differentiation in mammals. The Osx-Cre mouse line (also known as Osx1-GFP:: Cre) …
differentiation in mammals. The Osx-Cre mouse line (also known as Osx1-GFP:: Cre) …
The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation
The related transcriptional co-factors YAP (Yes-associated protein) and TAZ (transcriptional
co-activator with PDZ-binding motif) have been proposed to either promote or inhibit …
co-activator with PDZ-binding motif) have been proposed to either promote or inhibit …
Sirtuin1 (Sirt1) promotes cortical bone formation by preventing β-catenin sequestration by FoxO transcription factors in osteoblast progenitors
A decline of the levels and activity of Sirtuin1 (Sirt1), a NAD+ class III histone deacetylase,
with age contributes to the development of several diseases including type 2 diabetes …
with age contributes to the development of several diseases including type 2 diabetes …
Runt-related transcription factor 1 is required for murine osteoblast differentiation and bone formation
Despite years of research investigating osteoblast differentiation, the mechanisms by which
transcription factors regulate osteoblast maturation, bone formation, and bone homeostasis …
transcription factors regulate osteoblast maturation, bone formation, and bone homeostasis …