Influenza viruses replicate within the nucleus of the host cell. This uncommon RNA virus trait
provides influenza with the advantage of access to the nuclear machinery during replication …

An influenza pandemic happens when a novel influenza A virus is able to infect and transmit
efficiently to a new, distinct host species. Although the exact timing of pandemics is …

Coronavirus replication is associated with the remodeling of cellular membranes, resulting
in the formation of double-membrane vesicles (DMVs). A DMV-spanning pore was identified …

Interactions between respiratory viruses during infection affect transmission dynamics and
clinical outcomes. To identify and characterize virus–virus interactions at the cellular level …

The membrane-associated RING-CH (MARCH) proteins are E3 ligases that regulate the
stability of various cellular membrane proteins. MARCH8 has been reported to inhibit the …

Influenza A virus (IAV) enters cells by binding to sialic acid on the cell surface. To
accomplish this while avoiding immobilization by sialic acid in host mucus, viruses rely on a …

Influenza A virus causes millions of severe cases of disease during annual epidemics. The
most abundant protein in influenza virions is matrix protein 1 (M1), which mediates virus …

Influenza A virus haemagglutinin conformational change drives the membrane fusion of viral
and endosomal membranes at low pH. Membrane fusion proceeds through an intermediate …

Clinical isolates of influenza virus produce pleomorphic virus particles, including extremely
long filamentous virions. In contrast, strains of influenza that have adapted to laboratory …

There is a strong need for a new broad-spectrum antiinfluenza therapeutic, as vaccination
and existing treatments are only moderately effective. We previously engineered a lectin …