Mesenchymal stem cell-derived extracellular vesicle therapy for stroke: challenges and progress

OY Bang, EH Kim - Frontiers in neurology, 2019 - frontiersin.org
Stroke is the leading cause of physical disability among adults. Stem cells such as
mesenchymal stem cells (MSCs) secrete a variety of bioactive substances, including trophic …

Mesenchymal stem cell therapy for ischemic stroke: a look into treatment mechanism and therapeutic potential

J Li, Q Zhang, W Wang, F Lin, S Wang, J Zhao - Journal of neurology, 2021 - Springer
Stroke, a global disease with a high disability rate, has limited options for functional
rehabilitation and results in an adverse impact on patients' lives. In recent years …

Cerebral ischemia and neuroregeneration

RHC Lee, MHH Lee, CYC Wu, AC e Silva… - Neural regeneration …, 2018 - journals.lww.com
Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide.
Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 …

Cell based therapies for ischemic stroke: from basic science to bedside

X Liu, R Ye, T Yan, SP Yu, L Wei, G Xu, X Fan… - Progress in …, 2014 - Elsevier
Cell therapy is emerging as a viable therapy to restore neurological function after stroke.
Many types of stem/progenitor cells from different sources have been explored for their …

Progress in mesenchymal stem cell therapy for ischemic stroke

Y Guo, Y Peng, H Zeng, G Chen - Stem cells international, 2021 - Wiley Online Library
Ischemic stroke (IS) is a serious cerebrovascular disease with high morbidity and disability
worldwide. Despite the great efforts that have been made, the prognosis of patients with IS …

Mesenchymal stem/stromal cell therapy in blood–brain barrier preservation following ischemia: Molecular mechanisms and prospects

PT Do, CC Wu, YH Chiang, CJ Hu… - International journal of …, 2021 - mdpi.com
Ischemic stroke is the leading cause of mortality and long-term disability worldwide.
Disruption of the blood–brain barrier (BBB) is a prominent pathophysiological mechanism …

Paracrine effects of mesenchymal stem cells in ischemic stroke: Opportunities and challenges

A Asgari Taei, P Khodabakhsh, S Nasoohi… - Molecular …, 2022 - Springer
It is well acknowledged that neuroprotective effects of transplanted mesenchymal stem cells
(MSCs) in ischemic stroke are attributed to their paracrine-mediated actions or bystander …

Intranasal delivery of hypoxia-preconditioned bone marrow-derived mesenchymal stem cells enhanced regenerative effects after intracerebral hemorrhagic stroke in …

J Sun, ZZ Wei, X Gu, JY Zhang, Y Zhang, J Li… - Experimental neurology, 2015 - Elsevier
Intracerebral hemorrhagic stroke (ICH) causes high mortality and morbidity with very limited
treatment options. Cell-based therapy has emerged as a novel approach to replace …

[HTML][HTML] Adult stem cell therapy for stroke: challenges and progress

OY Bang, EH Kim, JM Cha, GJ Moon - Journal of stroke, 2016 - ncbi.nlm.nih.gov
Stroke is one of the leading causes of death and physical disability among adults. It has
been 15 years since clinical trials of stem cell therapy in patients with stroke have been …

[HTML][HTML] Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases

HE Gendelman, V Anantharam, T Bronich… - … , Biology and Medicine, 2015 - Elsevier
Interest in nanoneuromedicine has grown rapidly due to the immediate need for improved
biomarkers and therapies for psychiatric, developmental, traumatic, inflammatory, infectious …