Immunometabolism has emerged as a key focus for immunologists, with metabolic change
in immune cells becoming as important a determinant for specific immune effector …

Protein lipidation is an important co-or posttranslational modification in which lipid moieties
are covalently attached to proteins. Lipidation markedly increases the hydrophobicity of …

Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus known to cause epidemics
resulting in predominantly symptomatic infections, which in rare cases cause long term …

Abstract Toll-like receptor 9 (TLR9) recognizes self-DNA and plays intricate roles in systemic
lupus erythematosus (SLE). However, the molecular mechanism regulating the endosomal …

Post-translational attachment of lipids to proteins is found in all organisms, and is important
for many biological processes. Acylation with myristic and palmitic acids are among the most …

Despite all the advances of modern medicine, atherosclerosis continues to be one of the
most important medical and social problems. Atherosclerosis is the cause of several …

S-Acylation (commonly referred to as S-palmitoylation) is a post-translational modification
consisting in the covalent attachment of an acyl chain to a cysteine residue of the target …

Toll-like receptors (TLRs) are the important participants of the innate immune response.
Their spatial organization is well studied for the ligand-binding domains, while a lot of …

S-palmitoylation is a reversible, enzymatic posttranslational modification of proteins in which
palmitoyl chain is attached to a cysteine residue via a thioester linkage. S-palmitoylation …