Osteosarcoma is the most common primary malignant tumour of the bone. Osteosarcoma
incidence is bimodal, peaking at 18 and 60 years of age, and is slightly more common in …

Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children,
adolescents, and young adults, and with a second peak of incidence in elderly individuals …

Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers.
Although constituting only 1% of all human malignancies, sarcomas represent the second …

Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer
growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype …

The tumor microenvironment represents a complex network, in which tumor cells not only
communicate with each other but also with stromal and immune cells. Current research has …

The bone microenvironment is an ideal fertile soil for both primary and secondary tumors to
seed. The occurrence and development of osteosarcoma, as a primary bone tumor, is …

Abstract Development of functional nanomaterials is of great importance and significance for
advanced drug delivery and therapy. Nevertheless, exogenous nanomaterials have a great …

Exosomes are a subclass of extracellular vesicles involved in intercellular communication
that are released by all cell types, including cancer cells. Cancer exosomes carry malignant …

Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …