Background: Despite positive preclinical studies and two positive Phase II clinical trials, two
large Phase III clinical trials of progesterone treatment of acute traumatic brain injury (TBI) …

Progesterone has a broad spectrum of actions in the brain. Among these, the
neuroprotective effects are well documented. Progesterone neural effects are mediated by …

Hormone therapy, primarily progesterone and progestins, for central nervous system (CNS)
disorders represents an emerging field of regenerative medicine. Following a failed clinical …

The brain has long been known as a dimorphic organ and as a target of sex steroids. It is
also a site for their synthesis. Sex steroids in numerous ways can modify cerebral …

Stroke is the primary reason for death and disability worldwide, with few treatment strategies
to date. Neurosteroids, which are natural molecules in the brain, have aroused great interest …

Stroke and traumatic injuries of the brain and spinal cord are major public health issues. In
the last few decades, hundreds of clinical trials with patients suffering from these conditions …

Both sex and steroid hormones are important to consider in human ischemic stroke and its
experimental models. Stroke initiates a cascade of changes that lead to neural cell death …

Abstract Treatment with progesterone limits brain damage after stroke. However, the cellular
bases of the cerebroprotective effects of progesterone are not well documented. The aims of …

Our previous studies showed that intranasal delivery of progesterone offers a good
bioavailability and neuroprotective efficacy after experimental stroke. We have also …

The neuroscience community has largely accepted the notion that functional neurons can be
generated from neural stem cells in the adult brain, especially in two brain regions: the …