TREM2 in neurodegenerative diseases
TR Jay, VE von Saucken, GE Landreth - Molecular neurodegeneration, 2017 - Springer
TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …
TREM2-ligand interactions in health and disease
The protein triggering receptor expressed on myeloid cells-2 (TREM2) is an
immunomodulatory receptor with a central role in myeloid cell activation and survival. In …
immunomodulatory receptor with a central role in myeloid cell activation and survival. In …
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
Genetic variations in the myeloid immune receptor TREM2 are linked to several
neurodegenerative diseases. To determine how TREM2 variants contribute to these …
neurodegenerative diseases. To determine how TREM2 variants contribute to these …
A comprehensive review of immunoreceptor regulation of osteoclasts
MB Humphrey, MC Nakamura - Clinical reviews in allergy & immunology, 2016 - Springer
Osteoclasts require coordinated co-stimulation by several signaling pathways to initiate and
regulate their cellular differentiation. Receptor activator for NF-κB ligand (RANKL or …
regulate their cellular differentiation. Receptor activator for NF-κB ligand (RANKL or …
Triggering receptor expressed on myeloid cells receptor family modulators: a patent review
CJ Pelham, AN Pandya, DK Agrawal - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Triggering receptor expressed on myeloid cells (TREM) receptors and TREM-
like transcript (TLT; or TREML) receptors of the immunoglobulin superfamily are known as …
like transcript (TLT; or TREML) receptors of the immunoglobulin superfamily are known as …
Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model
J Morales-Ortíz, V Deal, F Reyes… - Blood, The Journal …, 2018 - ashpublications.org
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect> 200 000
individuals yearly with a 40% mortality rate. Although platelets are implicated in the …
individuals yearly with a 40% mortality rate. Although platelets are implicated in the …
The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis
Abstract The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-
surface molecules that control inflammation, bone homeostasis, neurological development …
surface molecules that control inflammation, bone homeostasis, neurological development …
Platelet biology of the rapidly failing lung
AV Washington, O Esponda… - British journal of …, 2020 - Wiley Online Library
Acute respiratory distress syndrome (ARDS) is characterized by a rapid‐onset respiratory
failure with a mortality rate of approximately 40%. This physiologic inflammatory process is …
failure with a mortality rate of approximately 40%. This physiologic inflammatory process is …
Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease
TE Golde, WJ Streit, P Chakrabarty - Alzheimer's research & therapy, 2013 - Springer
Genetic studies have provided the best evidence for cause and effect relationships in
Alzheimer's disease (AD). Indeed, the identification of deterministic mutations in the APP …
Alzheimer's disease (AD). Indeed, the identification of deterministic mutations in the APP …
The enigmatic nature of the triggering receptor expressed in myeloid cells-1 (TLT-1)
S Branfield, AV Washington - Platelets, 2021 - Taylor & Francis
Receptors are important pharmacological targets on cells. The Triggering Receptor
Expressed on Myeloid Cells (TREM)–Like Transcript–1 is an abundant, yet little understood …
Expressed on Myeloid Cells (TREM)–Like Transcript–1 is an abundant, yet little understood …