Mitochondrial heterogeneity and homeostasis through the lens of a neuron

G Pekkurnaz, X Wang - Nature metabolism, 2022 - nature.com
Mitochondria are vital organelles with distinct morphological features and functional
properties. The dynamic network of mitochondria undergoes structural and functional …

Energy matters: presynaptic metabolism and the maintenance of synaptic transmission

S Li, ZH Sheng - Nature Reviews Neuroscience, 2022 - nature.com
Synaptic activity imposes large energy demands that are met by local adenosine
triphosphate (ATP) synthesis through glycolysis and mitochondrial oxidative …

The functional impact of mitochondrial structure across subcellular scales

B Glancy, Y Kim, P Katti, TB Willingham - Frontiers in physiology, 2020 - frontiersin.org
Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

ZH Sheng, Q Cai - Nature Reviews Neuroscience, 2012 - nature.com
Mitochondria have a number of essential roles in neuronal function. Their complex mobility
patterns within neurons are characterized by frequent changes in direction. Mobile …

Miro proteins coordinate microtubule‐and actin‐dependent mitochondrial transport and distribution

G López‐Doménech, C Covill‐Cooke… - The EMBO …, 2018 - embopress.org
In the current model of mitochondrial trafficking, Miro1 and Miro2 Rho‐GTP ases regulate
mitochondrial transport along microtubules by linking mitochondria to kinesin and dynein …

Mitochondrial trafficking in neurons

TL Schwarz - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
Neurons, perhaps more than any other cell type, depend on mitochondrial trafficking for their
survival. Recent studies have elucidated a motor/adaptor complex on the mitochondrial …

Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch

P Anand, K Bley - British journal of anaesthesia, 2011 - academic.oup.com
Topical capsaicin formulations are used for pain management. Safety and modest efficacy of
low-concentration capsaicin formulations, which require repeated daily self-administration …

The axonal transport of mitochondria

WM Saxton, PJ Hollenbeck - Journal of cell science, 2012 - journals.biologists.com
Vigorous transport of cytoplasmic components along axons over substantial distances is
crucial for the maintenance of neuron structure and function. The transport of mitochondria …

Mitochondria: more than just a powerhouse

HM McBride, M Neuspiel, S Wasiak - Current biology, 2006 - cell.com
Pioneering biochemical studies have long forged the concept that the mitochondria are the
'energy powerhouse of the cell'. These studies, combined with the unique evolutionary origin …

Mitochondrial trafficking and anchoring in neurons: new insight and implications

ZH Sheng - Journal of Cell Biology, 2014 - rupress.org
Mitochondria are essential organelles for neuronal growth, survival, and function. Neurons
use specialized mechanisms to drive mitochondria transport and to anchor them in axons …