Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …

When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …

During mammalian pregnancy, the placenta acts as a barrier between the maternal and fetal
compartments. The recently observed association between Zika virus (ZIKV) infection during …

Type I interferon responses are considered the primary means by which viral infections are
controlled in mammals. Despite this view, several pathogens activate antiviral responses in …

Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as
the first line of defense against virus infection and regulate the development of both innate …

Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and
autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the …

Pregnancy is a unique condition where the maternal immune system is continuously
adapting in response to the stages of fetal development and signals from the environment …

Interferon (IFN)-λ forms the type III IFN family. Although they signal through distinct receptors,
type I (IFN-α/β) and type III IFNs elicit remarkably similar responses in cells. However, in …

The etiology of ulcerative colitis is poorly understood and is likely to involve perturbation of
the complex interactions between the mucosal immune system and the commensal bacteria …

Type III interferons (IFNs)(or IFN-λ) are the latest addition to the IFN family. Even though they
share little protein homology with type I IFN, both exhibit remarkable functional similarities …