The active metabolites of vitamin D3 (D3) and lumisterol (L3) exert a variety of antiaging and
photoprotective effects on the skin. These are achieved through immunomodulation and …

Vitamin D, referring to the two forms, D2 from the diet and D3 primarily derived from
phototransformation in the skin, is a prohormone important in human health. The most …

We have previously described new pathways of vitamin D3 activation by CYP11A1 to
produce a variety of metabolites including 20 (OH) D3 and 20, 23 (OH) 2 D3. These can be …

CYP11A1, a member of the cytochrome P450 family, plays several key roles in the human
body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to …

We tested whether novel CYP11A1-derived vitamin D 3-and lumisterol-hydroxyderivatives,
including 1, 25 (OH) 2 D 3, 20 (OH) D 3, 1, 20 (OH) 2 D 3, 20, 23 (OH) 2 D 3, 1, 20, 23 (OH) 3 …

A novel pathway of vitamin D activation by CYP11A has previously been elucidated. To
define the mechanism of action of its major dihydroxy-products, we tested the divergence …

Psoriasis is a systemic, chronic, immune-mediated disease that affects approximately 2–3%
of the world's population. The etiology and pathophysiology of psoriasis are still unknown …

For many individuals, in particular during winter, supplementation with the secosteroid
vitamin D3 is essential for the prevention of bone disorders, muscle weakness, autoimmune …

Vitamin D is the sunshine vitamin. During exposure to sunlight, 7-dehydrocholesterol in the
skin absorbs ultraviolet B (UVB) radiation converting it to previtamin D3. Previtamin D3 …

Novel pathways of vitamin D3, lumisterol 3 (L3), and tachysterol 3 (T3) activation have been
discovered, initiated by CYP11A1 and/or CYP27A1 in the case of L3 and T3. The resulting …