[HTML][HTML] Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed
Y Li, SS Hecht - International journal of molecular sciences, 2022 - mdpi.com
Carcinogenic N-nitrosamine contamination in certain drugs has recently caused great
concern and the attention of regulatory agencies. These carcinogens—widely detectable in …
concern and the attention of regulatory agencies. These carcinogens—widely detectable in …
Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools
AE Pegg - Chemical research in toxicology, 2011 - ACS Publications
O 6-Alkylguanine-DNA alkyltransferase (AGT) is a widely distributed, unique DNA repair
protein that acts as a single agent to directly remove alkyl groups located on the O 6-position …
protein that acts as a single agent to directly remove alkyl groups located on the O 6-position …
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection …
ME Dolan, RC Moschel… - Proceedings of the …, 1990 - National Acad Sciences
O6-Alkylguanine-DNA alkyltransferase was rapidly and irreversibly inactivated by exposure
to O6-benzylguanine or the p-chlorobenzyl and p-methylbenzyl analogues. This inactivation …
to O6-benzylguanine or the p-chlorobenzyl and p-methylbenzyl analogues. This inactivation …
Direct reversal of DNA alkylation damage
Y Mishina, EM Duguid, C He - Chemical reviews, 2006 - ACS Publications
Cellular DNA is constantly subjected to modifications by intracellular and extracellular
chemicals, which can result in covalent changes. 1, 2 Alkylating agents are one group of …
chemicals, which can result in covalent changes. 1, 2 Alkylating agents are one group of …
Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase
Escherichia coli expresses two DNA repair methyltransferases (MTases) that repair the
mutagenic O6-methylguanine (O6MeG) and O4-methylthymine (O4MeT) DNA lesions; one …
mutagenic O6-methylguanine (O6MeG) and O4-methylthymine (O4MeT) DNA lesions; one …
Cellular heterogeneity in DNA alkylation repair increases population genetic plasticity
MS Vincent, S Uphoff - Nucleic Acids Research, 2021 - academic.oup.com
DNA repair mechanisms fulfil a dual role, as they are essential for cell survival and genome
maintenance. Here, we studied how cells regulate the interplay between DNA repair and …
maintenance. Here, we studied how cells regulate the interplay between DNA repair and …
[HTML][HTML] Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive …
M Sassanfar, MK Dosanjh, JM Essigmann… - Journal of Biological …, 1991 - Elsevier
The suicidal inactivation mechanism of DNA repair methyltransferases (MTases) was
exploited to measure the relative efficiencies with which the Escherichia coli, human, and …
exploited to measure the relative efficiencies with which the Escherichia coli, human, and …
[HTML][HTML] Purification, structure, and biochemical properties of human O6-methylguanine-DNA methyltransferase.
G Koike, H Maki, H Takeya, H Hayakawa… - Journal of Biological …, 1990 - Elsevier
The level of O6-methylguanine-DNA methyltransferase activity in a human cell line carrying
a 1.1-kilobase cDNA fragment was about 50 times higher than that found in ordinary …
a 1.1-kilobase cDNA fragment was about 50 times higher than that found in ordinary …
Properties of mammalian O6-alkylguanine-DNA transferases
AE Pegg - … Research/Fundamental and Molecular Mechanisms of …, 1990 - Elsevier
Alkylating agents form a considerable number of different adducts on reaction with cellular
DNA (Singer and Grunberger, 1983; Pegg, 1983; Pegg and Singer, 1984; Saffhill et al …
DNA (Singer and Grunberger, 1983; Pegg, 1983; Pegg and Singer, 1984; Saffhill et al …
Inactivation of O6-Alkylguanine-DNA Alkyltransferase. 1. Novel O6-(Hetarylmethyl)guanines Having Basic Rings in the Side Chain
RS McElhinney, DJ Donnelly… - Journal of medicinal …, 1998 - ACS Publications
A number of novel guanine derivatives containing heterocyclic moieties at the O 6-position
have been synthesized using a purine quaternary salt which reacts with alkoxides under …
have been synthesized using a purine quaternary salt which reacts with alkoxides under …