Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …

Following infection, T cells differentiate into a heterogeneous population of effector T cells
that can mediate pathogen clearance. A subset of these effector T cells possesses the ability …

Severe SARS-CoV-2 infections are characterized by lymphopenia, but the mechanisms
involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized …

Our current understanding of immunology was largely defined in laboratory mice, partly
because they are inbred and genetically homogeneous, can be genetically manipulated …

Natural killer (NK) cells survey host tissues for signs of infection, transformation or stress
and, true to their name, kill target cells that have become useless or are detrimental to the …

Technological advances in recent years have allowed for an ever-expanding ability to
analyze and quantify in vivo immune responses. MHC tetramers, intracellular cytokine …

Weak T cell antigen receptor (TCR) signals from contact with self ligands act in synergy with
antiapoptotic signals induced by interleukin 7 (IL-7) to promote the survival of naive T cells in …

After an infection, T cells that carry the CD8 marker are activated and undergo a
characteristic kinetic sequence of rapid expansion, subsequent contraction and formation of …

Allogeneic haematopoietic stem-cell transplantation (SCT) is a curative therapy for
haematological malignancies and inherited disorders of blood cells, such as sickle-cell …

Death receptors (DRs) are members of the tumor necrosis factor receptor superfamily that
possess a cytoplasmic death domain (DD). DRs regulate important operational and …